Highlights/Supports:

• Natural Pain Relief Support
• Natural Anti-Inflammatory Support
• 600 Mg. Clinically Researched Dosage Per Cap

Natural Pain Relief & Inflammation Support
Ultra-Potent 600 Mg. Per Capsule

Palmitoylethanolamide (PEA) is a naturally occurring fatty acid amide that has been rapidly gaining in popularity and is commonly used for supporting the relief of pain and inflammation.

Palmitoylethanolamide has over 350+ clinical studies and has been shown to help with a variety of different types of pain including arthritis and joint pain, fibromyalgia, carpal tunnel, sciatica & lower back pain, migraines, irritable bowel, and more.

PEA Relief Highlights/Supports:
Natural Pain Relief Support
Natural Anti-Inflammatory Support
600 Mg. Clinically Researched Dosage

What is Palmitoylethanolamide?
Palmitoylethanolamide (commonly abbreviated as PEA), is a substance produced naturally in the body that can be isolated from a variety of foods. In the body, this fatty acid amide binds to a receptor in the cell nucleus known as the peroxisome proliferator-activated receptor. It plays a very important role within the cells in response to pain.

Palmitoylethanolamide has been shown in studies to demonstrate benefits for chronic pain and a variety of different types of pain including nerve pain, inflammatory pain, and more.

How does Palmitoylethanolamide Work?
Palmitoylethanolamide has been heavily researched and information about how it works, and its potential benefits is ever evolving. As of the time of writing this, it is estimated to have been the subject of at least 350+ studies.

There have been many established mechanisms by which Palmitoylethanolamide is thought to work, many of which will be mentioned below in this write up. However, it is widely believed that this incredible ingredient may also work in other ways that haven’t been established yet.

A few examples of mechanisms of action of Palmitoylethanolamide are that it plays a role in reducing inflammation, reducing mast cell activation, enhancing endocannabinoid activity, and having positive effects on several different types of receptors in the body that influence pain perception.

Let’s Examine the Potential Benefits:
Palmitoylethanolamide has such a vast array of potential benefits that an entire series of articles could be written on it. For the purposes of this write up, we will attempt to touch on a variety of them but will keep the amount of detail brief for ease of readability and space constraints.

Natural Pain Relief & Inflammation Support:
Palmitoylethanolamide is found naturally in the body and its levels increase when tissue damage occurs.

Palmitoylethanolamide has been shown to help reduce inflammation and pain associated with a variety of conditions including arthritis, neuropathic (nerve) pain, injuries, migraines, and chronic pain syndromes such as fibromyalgia, lower back pain, sciatica, and more.

One study found that when people took a daily supplement of 600 mg. of Palmitoylethanolamide, 88% reported being able to move around more comfortably and 82% reported a 50% or greater reduction in pain severity within 3 weeks.

A very interesting and unique aspect of Palmitoylethanolamide is that it helps support pain relief and inflammation in quite a few different ways, making it a multi-faceted approach to natural pain relief and inflammation support.

COX-2:

Research has shown that levels of cyclooxygenase-2 (COX-2) are elevated during periods of pain and inflammation, including neuroinflammation.

Palmitoylethanolamide has been shown to work by inhibiting the production of inflammatory mediators, such as cyclooxygenase-2 (COX-2) and interleukin-1β (IL-1β). It has also been shown to stimulate the production of anti-inflammatory factors, such as IL-10.

Endocannabinoid System:

Palmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator that plays an important biological role within cells in response to pain. It has extensively documented anti-inflammatory properties and is commonly used for supporting the relief of pain and inflammation.

Endocannabinoids are released by the body to help control the immune response when there is an injury or inflammation. Palmitoylethanolamide helps increase the levels of endocannabinoids in the body, ultimately leading to reduced pain and inflammation.

Nerve Pain:

Palmitoylethanolamide has been shown to reduce the release of inflammatory chemicals and reduce overall nerve inflammation. This makes it unique in its role of being able to help with certain types of pain that many other natural supplements aren’t able to, such as sciatica and carpal tunnel.

Palmitoylethanolamide has also been reported to inhibit the release of proinflammatory mediators from activated mast cells and reduce mast cell recruitment and activation at sites of nerve injury. Palmitoylethanolamide treatment has even been shown to inhibit microglial activation and mast cell recruitment to the spinal cord following peripheral nerve injury, spinal cord neuroinflammation, or spinal cord injury.

Joint Health & Mobility:
Palmitoylethanolamide has been shown in numerous clinical studies to support a reduction in arthritis related pain, inflammation, and stiffness.

Lower Back Pain & Sciatica:
Palmitoylethanolamide has been shown in studies to help with lower back pain and sciatica. In one study on people with lower back pain and sciatica, for every seven patients treated, approximately four received significant pain relief with PEA supplementation.

Carpal Tunnel:
Palmitoylethanolamide has been shown to help with nerve pain, and a study on Palmitoylethanolamide in people with carpal tunnel syndrome found improved sleep and decreased pain with its use.

Migraines:
Palmitoylethanolamide has been shown to effectively reduce pain during migraines in some people. The mechanism of action of Palmitoylethanolamide is not entirely clear but is thought to involve the regulation of inflammatory mediators such as prostaglandins and cytokines.

In a 2022 study, 25 patients with migraines were given Palmitoylethanolamide. The study found that the number of days with headaches decreased from 10 per month to 6.6 per month and that pain medication use was also reduced. Another study done on children over the course of three months showed that supplementing with Palmitoylethanolamide cut migraine frequency in half while also decreasing their severity.

Cognitive Health & Nootropic Support:
Palmitoylethanolamide is a natural fatty acid that is made in the brain and has anti-inflammatory and neuroprotective effects.

Palmitoylethanolamide has been shown to stimulate healthy brain cells, reduce inflammation in the brain, and to help protect neurons from excitotoxicity, oxidative stress, and cell death induced by inflammatory mediators.

It has also been shown to help support neurobehavioral functions, including memory and learning, by reducing oxidative stress and pro-inflammatory marker expression as well as rebalancing glutamatergic transmission.

Healthy Aging:
The term healthy aging can mean different things to different people, and many of the benefits of Palmitoylethanolamide discussed in this section may meet many people’s definitions.

Combating inflammation is a popular topic in terms of longevity and anti-aging discussion, and Palmitoylethanolamide has exciting potential for its natural anti-inflammatory potential.

In addition, Palmitoylethanolamide is believed to act as an anti-aging supplement by helping to protect cells from oxidative damage, which is a leading reason of why people age.

Oxidation occurs when cells are exposed to free radical activity and damage, which can lead to cell death. This can be contributed to by the way we eat, many of the bad habits that we may have, or other environmental factors such as air pollution, and much more. Palmitoylethanolamide may help to reduce this damage by scavenging free radicals and reducing overall inflammation in the body.

Athletic Performance & Recovery:
Palmitoylethanolamide may support improved athletic performance and recovery by helping to reduce inflammation and promoting healing. It has also been shown to support improved protein synthesis.

Gut Health – Leaky Gut, Irritable Bowel, and More:
Studies have shown that Palmitoylethanolamide may protect the lining of the gastrointestinal tract, reduce inflammation, and support the regulation of processes such as gut movement and digestion.

Leaky Gut:

The gut barrier helps keep harmful toxins from being absorbed into one’s bloodstream, which can have adverse effects on one’s brain and body.

Studies indicate that Palmitoylethanolamide may improve gut permeability and be helpful for those who have a leaky gut, a condition where the gut barrier is impaired. Leaky gut has been associated with migraines, fibromyalgia, autoimmune conditions, and more.

Inflammatory Bowel:

Many researchers view Palmitoylethanolamide as a promising ingredient for inflammatory bowel disorders due to its ability to reduce inflammation via multiple pathways.

Irritable Bowel:

Palmitoylethanolamide may support a reduction in symptoms of irritable bowel by helping improve gut permeability and inflammation.

A recent clinical study showed that people with irritable bowel syndrome experienced a reduction in abdominal pain with Palmitoylethanolamide.

Cardiovascular Health Support:
Palmitoylethanolamide is and has been the subject of a number of studies showing that it has the potential to support heart health in a number of ways.

A recent study’s conclusion stated:

The present study demonstrates that Palmitoylethanolamide protects against atherosclerosis by promoting an anti-inflammatory and pro-resolving phenotype of lesional macrophages, representing a new therapeutic approach to resolve arterial inflammation.

Immune Health & Respiratory Health Support:
Palmitoylethanolamide has been shown in studies to help support improvements in symptoms of influenza and respiratory infections and has also been shown to contribute to a reduction in the overall number of days of reported sickness.

Palmitoylethanolamide possesses anti-inflammatory properties which can reduce the production of pro-inflammatory signals and support inhibiting the activation of immune cells involved in inflammation. The beneficial effects of PEA on immune function have been documented in over 350 peer-reviewed studies.

A review paper from 2013 concluded that studies on over 4000 patients documented the safety and efficacy of PEA against colds and flu. Based on the data, they concluded that PEA should be considered in the treatment of respiratory tract infections.

There have been a number of papers published and at least one study suggesting that Palmitoylethanolamide may have beneficial effects on Covid and Long Covid symptoms.

Allergy Support:
Allergic reaction symptoms are the immune system’s response to a perceived threat. When exposed to a trigger (allergen), the body releases histamine, which can cause symptoms such as itching, swelling, and increased mucus production.

Palmitoylethanolamide is thought to help support allergy relief by reducing the release of histamines from mast cells.

How to Use PEA Relief:
PEA Relief should be used daily for best results.

Many people will see results quickly with PEA Relief, but most people start to see the most significant results with Palmitoylethanolamide start in 2 to 4 weeks and increase and get better with time as Palmitoylethanolamide levels build up in the body.

Stacking and Synergy:
SNS PEA Relief can be used with Joint Support XT, Elite Curcumin, Theracurmin XT, Focus XT, Cardiovascular Support XT, &/or a wide variety of other SNS products to help you reach your health and fitness goals.